Nod2^tm1.1Kuv
Targeted Allele Detail

Summary

• Symbol: Nod2^tm1.1Kuv
• Name: nucleotide-binding oligomerization domain containing 2; targeted mutation 1.1, Universitat Kiel
• MGI ID: MGI:5823263
• Synonyms: NGF5 Flox, Nod2^fl, Nod2^tm1.1Geno
• Gene: Nod2 Location: Chr8:89373943-89415102 bp, + strand Genetic Position: Chr8, 43.51 cM, cytoband C3
• Alliance: Nod2^tm1.1Kuv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235186
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 1 and an FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted within intnron 3. Flp-mediated recombination in mice removed the selection cassette and left exons 2 through 3 flanked by loxP sites. (J:235186)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nod2 Mutation: 63 strains or lines available

References

• Original: J:235186 Kim D, et al., Nod2-mediated recognition of the microbiota is critical for mucosal adjuvant activity of cholera toxin. Nat Med. 2016 May;22(5):524-30
• All: 11 reference(s)