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Lpcat3tm1c(EUCOMM)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Lpcat3tm1c(EUCOMM)Wtsi
Name: lysophosphatidylcholine acyltransferase 3; targeted mutation 1c, Wellcome Trust Sanger Institute
MGI ID: MGI:5822780
Synonyms: F, Lpcat3fl
Gene: Lpcat3  Location: Chr6:124639990-124681381 bp, + strand  Genetic Position: Chr6, 59.17 cM
Mutation
origin
Mutant Cell Line:  EPD0455_5_A07
Germline Transmission:  Earliest citation of germline transmission: J:220827
Parent Cell Line:  JM8A1.N3 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion     Vector: L1L2_Bact_P
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 124698768 of Chromosome 6 upstream of the critical exon 3 (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 3 at position 124699594. Flp-mediated recombination removed the reporter and selection cassettes and left exon 3 floxed. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:220827)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lpcat3 Mutation:  17 strains or lines available
References
Original:  J:220827 Rong X, et al., Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion. Elife. 2015;4
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2022
MGI 6.20
The Jackson Laboratory