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Blvratm1c(EUCOMM)Hmgu
Targeted Allele Detail
Summary
Symbol: Blvratm1c(EUCOMM)Hmgu
Name: biliverdin reductase A; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
MGI ID: MGI:5816874
Gene: Blvra  Location: Chr2:126912585-126939004 bp, + strand  Genetic Position: Chr2, 61.76 cM, cytoband F3
Alliance: Blvratm1c(EUCOMM)Hmgu page
IMPC: Blvra gene page
Mutation
origin
Mutant Cell Line:  HEPD0510_3_B01
Germline Transmission:  Earliest citation of germline transmission: J:237631
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion     Vector: L1L2_Bact_P
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 126924416 of Chromosome 2 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 126925207. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). (J:237631)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Blvra Mutation:  32 strains or lines available
References
Original:  J:237631 Hinds TD Jr, et al., Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3beta Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) alpha. J Biol Chem. 2016 Nov 25;291(48):25179-25191
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory