Slc17a8^tm1.2Seal
Targeted Allele Detail

Summary

• Symbol: Slc17a8^tm1.2Seal
• Name: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8; targeted mutation 1.2, Rebecca Seal
• MGI ID: MGI:5806055
• Synonyms: VGLUT3^delta
• Gene: Slc17a8 Location: Chr10:89409882-89457111 bp, - strand Genetic Position: Chr10, 44.99 cM
• Alliance: Slc17a8^tm1.2Seal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227670
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 2. An additional loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 2. Western blot analysis confirmed the absence of protein expression in the brain. (J:227670)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc17a8 Mutation: 42 strains or lines available

References

• Original: J:227670 Peirs C, et al., Dorsal Horn Circuits for Persistent Mechanical Pain. Neuron. 2015 Aug 19;87(4):797-812
• All: 2 reference(s)