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Transgene Detail
Symbol: Tg(Myh6*/tetO-SCN5A*F1759A)#Marx
Name: transgene insertion, Steven O Marx
MGI ID: MGI:5800483
Synonyms: F1759A-Nav1.5
Transgene: Tg(Myh6*/tetO-SCN5A*F1759A)#Marx  Location: unknown  
Atrial and ventricular cardiomyopathy in Tg(Myh6*/tetO-SCN5A*F1759A)#Marx/0 Tg(Myh6-rtTA)8585Jam/0 mice

Show the 1 phenotype image(s) involving this allele.

Strain of Origin:  Not Specified
Transgene Type:    Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
Inducer:    doxycycline/tetracycline
Mutation:    Insertion
Tg(Myh6*/tetO-SCN5A*F1759A)#Marx expresses 1 gene
Mutation detailsA FLAG-tagged human SCN5A cDNA with the F1759A mutation in the local anesthetic binding site is under the control of a tetracycline-inducible modified murine alpha-MHC promoter. This mutation results in lidocaine-resistance and causes window current and persistent sodium current. Four lines were established however, the pound symbol (#) is used when line is not specified and/or lines are pooled. (J:229825)
Schematic of the Tg(Myh6*/tetO-SCN5A*F1759A)#Marx construct
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:229825 Wan E, et al., Aberrant sodium influx causes cardiomyopathy and atrial fibrillation in mice. J Clin Invest. 2016 Jan;126(1):112-22
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.19
The Jackson Laboratory