Nrxn2^tm2.2Sud
Targeted Allele Detail

Summary

• Symbol: Nrxn2^tm2.2Sud
• Name: neurexin II; targeted mutation 2.2, Thomas C Sudhof
• MGI ID: MGI:5796033
• Gene: Nrxn2 Location: Chr19:6468786-6583247 bp, + strand Genetic Position: Chr19, 4.65 cM
• Alliance: Nrxn2^tm2.2Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:224592
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into the 5' end of a modified exon 17, which contains an hemagglutinin (HA) reporter tag followed by a FRT-flanked neomycin resistance cassette and a loxP site. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed the modified exon 17. (J:224592)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nrxn2 Mutation: 91 strains or lines available

References

• Original: J:224592 Anderson GR, et al., beta-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling. Cell. 2015 Jul 30;162(3):593-606
• All: 2 reference(s)