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Pnkptm1.1Pmc
Targeted Allele Detail
Nomenclature
Symbol: Pnkptm1.1Pmc
Name: polynucleotide kinase 3'- phosphatase; targeted mutation 1.1, Peter J McKinnon
MGI ID: MGI:5795744
Synonyms: PnkploxP
Gene: Pnkp  Location: Chr7:44857139-44862992 bp, + strand  Genetic Position: Chr7, 28.94 cM, cytoband B2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:226703
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA single loxP site was introduced between exons 7 and 8 and a neomycin selection cassette flanked by frt sites with a single loxP site was inserted between exons 3 and 4. Flp-mediated recombination removed the neomycin cassette leaving exons 4-7 flanked by loxP sites. (J:226703)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 4 assay results
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pnkp Mutation:  8 strains or lines available
References
Original:  J:226703 Shimada M, et al., Polynucleotide kinase-phosphatase enables neurogenesis via multiple DNA repair pathways to maintain genome stability. EMBO J. 2015 Oct 1;34(19):2465-80
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory