Plk1^tm1Gdcr
Targeted Allele Detail

Summary

• Symbol: Plk1^tm1Gdcr
• Name: polo like kinase 1; targeted mutation 1, Guillermo de Carcer
• MGI ID: MGI:5793054
• Synonyms: Plk1(lox)
• Gene: Plk1 Location: Chr7:121758662-121769096 bp, + strand Genetic Position: Chr7, 65.52 cM
• Alliance: Plk1^tm1Gdcr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235197
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutations: Insertion, Intragenic deletion
• Exon 2 was floxed. A neomycin resistance cassette was inserted into the locus. (J:235197)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plk1 Mutation: 30 strains or lines available

References

• Original: J:235197 Wachowicz P, et al., Genetic depletion of Polo-like kinase 1 leads to embryonic lethality due to mitotic aberrancies. Bioessays. 2016 Jul;38 Suppl 1:S96-S106
• All: 3 reference(s)