Itpkb^tm1.1Gnf
Targeted Allele Detail

Summary

• Symbol: Itpkb^tm1.1Gnf
• Name: inositol 1,4,5-trisphosphate 3-kinase B; targeted mutation 1.1, Genomics Institute of the Novartis Research Foundation
• MGI ID: MGI:5792880
• Synonyms: Itpkb^fl
• Gene: Itpkb Location: Chr1:180158050-180252367 bp, + strand Genetic Position: Chr1, 84.27 cM, cytoband H5
• Alliance: Itpkb^tm1.1Gnf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:233881
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette and left exon 2 floxed. (J:233881)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itpkb Mutation: 40 strains or lines available

References

• Original: J:233881 Miller AT, et al., Inhibition of the Inositol Kinase Itpkb Augments Calcium Signaling in Lymphocytes and Reveals a Novel Strategy to Treat Autoimmune Disease. PLoS One. 2015;10(6):e0131071
• All: 2 reference(s)