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Targeted Allele Detail
Symbol: Esyt3tm1d(EUCOMM)Wtsi
Name: extended synaptotagmin-like protein 3; targeted mutation 1d, Wellcome Trust Sanger Institute
MGI ID: MGI:5792823
Synonyms: 3KO, Esty3 delta
Gene: Esyt3  Location: Chr9:99192016-99240610 bp, - strand  Genetic Position: Chr9, 51.54 cM
Mutant Cell Line:  EPD0458_5_A10
Germline Transmission:  Earliest citation of germline transmission: J:232605
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: EUCOMM
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion     Vector: L1L2_Bact_P
Mutation detailsCre- and Flp-mediated excision of the parental Esyt3tm1a(EUCOMM)Wtsi allele resulted in the removal of the promoter-driven neomycin selection cassette, the IRES-BetaGal reporter expression cassette and critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:232605)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 57 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Esyt3 Mutation:  28 strains or lines available
Original:  J:232605 Herdman C, et al., Loss of Extended Synaptotagmins ESyt2 and ESyt3 does not affect mouse development or viability, but in vitro cell migration and survival under stress are affected. Cell Cycle. 2014;13(16):2616-25
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory