All Phenotypes Esyt3<tm1d(EUCOMM)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Esyt3^{tm1d(EUCOMM)Wtsi}
targeted mutation 1d, Wellcome Trust Sanger Institute
MGI:5792823

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Esyt3^{tm1d(EUCOMM)Wtsi}/Esyt3^{tm1d(EUCOMM)Wtsi}	involves: C57BL/6N	MGI:5896574
cx2	Esyt2^{Gt(AN0678)Wtsi}/Esyt2^{Gt(AN0678)Wtsi} Esyt3^{tm1d(EUCOMM)Wtsi}/Esyt3^{tm1d(EUCOMM)Wtsi}	involves: 129P2/OlaHsd * C57BL/6N	MGI:5896572

Allelic Composition	Esyt3^{tm1d(EUCOMM)Wtsi}/Esyt3^{tm1d(EUCOMM)Wtsi}
Genetic Background	involves: C57BL/6N
Cell Lines	EPD0458_5_A10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Esyt3^{tm1d(EUCOMM)Wtsi} mutation (1 available); any Esyt3 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:232605 )

• mice are viable and fertile without overt morphological defects

Allelic Composition	Esyt2^{Gt(AN0678)Wtsi}/Esyt2^{Gt(AN0678)Wtsi} Esyt3^{tm1d(EUCOMM)Wtsi}/Esyt3^{tm1d(EUCOMM)Wtsi}
Genetic Background	involves: 129P2/OlaHsd * C57BL/6N
Cell Lines	EPD0458_5_A10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Esyt2^{Gt(AN0678)Wtsi} mutation (1 available); any Esyt2 mutation (43 available)
Esyt3^{tm1d(EUCOMM)Wtsi} mutation (1 available); any Esyt3 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:232605 )

• fewer than expected mice are born

• however, surviving mice exhibit normal development, viability, survival, reproduction and organ development (lung, testis and spleen)

cellular

increased sensitivity to induced cell death ( J:232605 )

• mouse embryonic fibroblasts are less resistance to FGF serum withdrawal compared with control cells

increased cellular sensitivity to oxidative stress ( J:232605 )

• in mouse embryonic fibroblasts

decreased cell migration ( J:232605 )

• of FGF-stimulated mouse embryonic fibroblasts

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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