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Myo5btm1.1Cle
Targeted Allele Detail
Nomenclature
Symbol: Myo5btm1.1Cle
Name: myosin VB; targeted mutation 1.1, Hans Clevers
MGI ID: MGI:5790962
Synonyms: Myo5bfl
Gene: Myo5b  Location: Chr18:74442364-74772698 bp, + strand  Genetic Position: Chr18, 50.7 cM
Microvillus inclusion disease phenotype in Myo5btm1.1Cle/Myo5btm1.1Cle Tg(Vil1-cre/ERT2)23Syr/0 mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:227079
Parent Cell Line:  IB10/E14IB10 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsLoxP sites were inserted flanking exon 4. An FRT-flanked neomycin resistance cassette was inserted upstream of exon 4. Flp-mediated recombination removed the neo cassette and left exon 4 floxed. (J:227079)
Generation of the Myo5btm1.1Cle allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myo5b Mutation:  2 strains or lines available
References
Original:  J:227079 Schneeberger K, et al., An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral trafficking. Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):12408-13
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory