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Targeted Allele Detail
Symbol: Olfr151tm39(Gnas*)Mom
Name: olfactory receptor 151; targeted mutation 39, Peter Mombearts
MGI ID: MGI:5784884
Synonyms: M71(RDY)-caGs-GFP
Gene: Olfr151  Location: Chr9:37641273-37642357 bp, - strand  Genetic Position: Chr9, 20.8 cM
Germline Transmission:  Earliest citation of germline transmission: J:233447
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Constitutively active, Hypomorph, Inserted expressed sequence)
Mutations:    Insertion, Nucleotide substitutions
Olfr151tm39(Gnas*)Mom expresses 1 gene
Mutation detailsTwo amino acid substitutions (D121R;R122D) were made to change the highly conserved DRY motif to RDY to diminish G-protein signalling, and an internal ribosome entry site followed by a constitutively active Gnas coding sequence (due to a Q227L sequence change) was inserted just downstream of the endogenous coding sequence to give bicistronic expression. (J:233447)
Inheritance:    Not Specified
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Olfr151 Mutation:  61 strains or lines available
Original:  J:233447 Movahedi K, et al., Odorant receptors can mediate axonal identity and gene choice via cAMP-independent mechanisms. Open Biol. 2016 Jul;6(7)
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory