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Olfr151tm39(Gnas*)Mom
Targeted Allele Detail
Nomenclature
Symbol: Olfr151tm39(Gnas*)Mom
Name: olfactory receptor 151; targeted mutation 39, Peter Mombearts
MGI ID: MGI:5784884
Synonyms: M71(RDY)-caGs-GFP
Gene: Olfr151  Location: Chr9:37641273-37642357 bp, - strand  Genetic Position: Chr9, 20.8 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:233447
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Constitutively active, Hypomorph, Inserted expressed sequence)
Mutations:    Insertion, Nucleotide substitutions
 
Olfr151tm39(Gnas*)Mom expresses 1 gene
 
Mutation detailsTwo amino acid substitutions (D121R;R122D) were made to change the highly conserved DRY motif to RDY to diminish G-protein signalling, and an internal ribosome entry site followed by a constitutively active Gnas coding sequence (due to a Q227L sequence change) was inserted just downstream of the endogenous coding sequence to give bicistronic expression. (J:233447)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Olfr151 Mutation:  61 strains or lines available
References
Original:  J:233447 Movahedi K, et al., Odorant receptors can mediate axonal identity and gene choice via cAMP-independent mechanisms. Open Biol. 2016 Jul;6(7)
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory