Klhl20^tm1.1Rhch
Targeted Allele Detail

Summary

• Symbol: Klhl20^tm1.1Rhch
• Name: kelch-like 20; targeted mutation 1.1, Ruey-Hwa Chen
• MGI ID: MGI:5781141
• Synonyms: KLHL20^fl/fl
• Gene: Klhl20 Location: Chr1:160915945-160959078 bp, - strand Genetic Position: Chr1, 69.75 cM
• Alliance: Klhl20^tm1.1Rhch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:232813
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The gene was targeted with a vector containing a loxP site in intron 2 and an FRT-neo-FRT-loxP cassette in intron 6. Subsequent FLP-mediated recombination excised the neo cassette, leaving exons 3-6 floxed. (J:232813)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klhl20 Mutation: 36 strains or lines available

References

• Original: J:232813 Liu CC, et al., Cul3-KLHL20 Ubiquitin Ligase Governs the Turnover of ULK1 and VPS34 Complexes to Control Autophagy Termination. Mol Cell. 2016 Jan 7;61(1):84-97
• All: 1 reference(s)