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Targeted Allele Detail
Symbol: Aldh1b1tm1Vvas
Name: aldehyde dehydrogenase 1 family, member B1; targeted mutation 1, Vasilis Vasiliou
MGI ID: MGI:5779307
Gene: Aldh1b1  Location: Chr4:45799022-45804604 bp, + strand  Genetic Position: Chr4, 24.35 cM, cytoband B2
Germline Transmission:  Earliest citation of germline transmission: J:228677
Parent Cell Line:  EC7.1 (ES Cell)
Strain of Origin:  (C57BL/6J x 129X1/SvJ)F1
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA floxed neomycin resistance cassette replaced the coding sequence in exon 2. Western blot analysis confirmed the absence of protein expression in the liver, small intestine and colon. (J:228677)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aldh1b1 Mutation:  21 strains or lines available
Original:  J:228677 Singh S, et al., ALDH1B1 links alcohol consumption and diabetes. Biochem Biophys Res Commun. 2015 Aug 7;463(4):768-73
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
The Jackson Laboratory