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Aldh1b1tm1Vvas
Targeted Allele Detail
Nomenclature
Symbol: Aldh1b1tm1Vvas
Name: aldehyde dehydrogenase 1 family, member B1; targeted mutation 1, Vasilis Vasiliou
MGI ID: MGI:5779307
Gene: Aldh1b1  Location: Chr4:45799022-45804604 bp, + strand  Genetic Position: Chr4, 24.35 cM, cytoband B2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:228677
Parent Cell Line:  EC7.1 (ES Cell)
Strain of Origin:  (C57BL/6J x 129X1/SvJ)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neomycin resistance cassette replaced the coding sequence in exon 2. Western blot analysis confirmed the absence of protein expression in the liver, small intestine and colon. (J:228677)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aldh1b1 Mutation:  21 strains or lines available
References
Original:  J:228677 Singh S, et al., ALDH1B1 links alcohol consumption and diabetes. Biochem Biophys Res Commun. 2015 Aug 7;463(4):768-73
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory