Jarid2^{tm1c(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Jarid2^{tm1c(KOMP)Wtsi}
• Name: jumonji and AT-rich interaction domain containing 2; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:5779200
• Synonyms: Jarid2^fl, Jarid2^flox
• Gene: Jarid2 Location: Chr13:44882950-45075119 bp, + strand Genetic Position: Chr13, 21.66 cM
• Alliance: Jarid2^{tm1c(KOMP)Wtsi} page
• IMPC: Jarid2 gene page

Mutation origin

• Mutant Cell Line: EPD0018_2_A08
• Germline Transmission: Earliest citation of germline transmission: J:232066
• Parent Cell Line: JM8 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion Vector: L1L2_gt0
• Mutation details: The L1L2_gt0 cassette was inserted at position 44976315 of Chromosome 13 upstream of the critical exon 2 (Build GRCm39; exon 3 in transcript ENSMUST00000044608). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon 2 (exon 3 in transcript ENSMUST00000044608) at position 44977253. The critical exon 2 (exon 3 in transcript ENSMUST00000044608) is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:232066)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jarid2 Mutation: 374 strains or lines available

References

• Original: J:232066 Escobar TM, et al., miR-155 activates cytokine gene expression in Th17 cells by regulating the DNA-binding protein Jarid2 to relieve polycomb-mediated repression. Immunity. 2014 Jun 19;40(6):865-79
• All: 3 reference(s)