Kcnj13^em6Mrd
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kcnj13^em6Mrd
• Name: potassium inwardly-rectifying channel, subfamily J, member 13; endonuclease-mediated mutation 6, Graeme Mardon
• MGI ID: MGI:5775298
• Synonyms: Kcnj13^N13
• Gene: Kcnj13 Location: Chr1:87314085-87322451 bp, - strand Genetic Position: Chr1, 44.3 cM
• Alliance: Kcnj13^em6Mrd page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas technology was used to generate mutations near the start codon. This line contains a 3 bp deletion at the targeted site. (J:227161)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnj13 Mutation: 22 strains or lines available

Notes

Mice homozygous or transheterozygous for candidate Kcnj13 null alleles are postnatal lethal. J:227161

References

• Original: J:227161 Zhong H, et al., CRISPR-engineered mosaicism rapidly reveals that loss of Kcnj13 function in mice mimics human disease phenotypes. Sci Rep. 2015;5:8366
• All: 1 reference(s)