Nod2^tm1.1Mpdy
Targeted Allele Detail

Summary

• Symbol: Nod2^tm1.1Mpdy
• Name: nucleotide-binding oligomerization domain containing 2; targeted mutation 1.1, Michael P Davey
• MGI ID: MGI:5767092
• Synonyms: R314Q-Nod2 KI
• Gene: Nod2 Location: Chr8:89373943-89415102 bp, + strand Genetic Position: Chr8, 43.51 cM, cytoband C3
• Alliance: Nod2^tm1.1Mpdy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:230689
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Single point mutation
• Mutation details: Exon 4 was replaced with an FRT-flanked neomycin resistance cassette and a modified exon 4 in which a G to A point mutation results in the amino acid substitution of glutamine for arginine at position 314 (R314Q). Flp-mediated recombination removed the selection cassette. (J:230689)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nod2 Mutation: 63 strains or lines available

References

• Original: J:230689 Dugan J, et al., Blau syndrome-associated Nod2 mutation alters expression of full-length NOD2 and limits responses to muramyl dipeptide in knock-in mice. J Immunol. 2015 Jan 1;194(1):349-57
• All: 1 reference(s)