Psmb11^em1Hasu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Psmb11^em1Hasu
• Name: proteasome (prosome, macropain) subunit, beta type, 11; endonuclease-mediated mutation 1, Harumi Suzuki
• MGI ID: MGI:5763098
• Synonyms: Psmb11^G220R
• Gene: Psmb11 Location: Chr14:54862767-54867013 bp, + strand Genetic Position: Chr14, 27.87 cM
• Alliance: Psmb11^em1Hasu page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated
• Mutation: Single point mutation
• Mutation details: CRISPR technology was used to generate a G to A nucleotide substitution that results in the amino acid substitution of arginine for glycine at position 220 (G220R). Founder 2 is heterozygous for the expected point mutation wthout any additional mutations. Founder 28 is heterozygous for the expected point mutation without any additional mutations. (J:222872)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Psmb11 Mutation: 10 strains or lines available

Notes

Guide RNA and hCas9 mRNA were injected into fertilized eggs from either (C57BL/6 x DBA/2)F1 x C57BL/6-Psmb11^Tn or C57BL/6 x C57BL/6-Psmb11^Tn.

References

• Original: J:222872 Nitta T, et al., The thymic cortical epithelium determines the TCR repertoire of IL-17-producing gammadeltaT cells. EMBO Rep. 2015 May;16(5):638-53
• All: 1 reference(s)