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Tg(BEST1-HTRA1)44Ybf
Transgene Detail
Nomenclature
Symbol: Tg(BEST1-HTRA1)44Ybf
Name: transgene insertion 44, Yingbin Fu
MGI ID: MGI:5758950
Synonyms: hHTRA1+ Tg44
Transgene: Tg(BEST1-HTRA1)44Ybf  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x CBA)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
    The human HTRA1 cDNA is under the control of the human VMD2 promoter. (J:175227, J:230011)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Phenotypic Similarity to Human Syndrome: Polypoidal Choroidal Vasculopathy J:230011.
References
Original:  J:230011 Kumar S, et al., Angiographic features of transgenic mice with increased expression of human serine protease HTRA1 in retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2014 Jun;55(6):3842-50
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/12/2020
MGI 6.15
The Jackson Laboratory