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Grm6nob7
Spontaneous Allele Detail
Nomenclature
Symbol: Grm6nob7
Name: glutamate receptor, metabotropic 6; no b wave 7
MGI ID: MGI:5754842
Gene: Grm6  Location: Chr11:50850685-50866208 bp, + strand  Genetic Position: Chr11, 30.93 cM
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Spontaneous (Null/knockout)
Mutation:    Single point mutation
 
Mutation detailsThis spontaneous G to A point transition at the last position in exon 8 disrupts spicing and extends the normal exon 8 by 28 bp resulting in a frameshift, and immunohistochemistry does not detect this protein in the dendritic tips of depolariing bipolar cells in the retina indicating that this is a null allele. (J:229885)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grm6 Mutation:  31 strains or lines available
References
Original:  J:229885 Qian H, et al., Identification of a new mutant allele, Grm6(nob7), for complete congenital stationary night blindness. Vis Neurosci. 2015 Jan;32:E004
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory