Kcnj6^tm1.1Kwn
Targeted Allele Detail

Summary

• Symbol: Kcnj6^tm1.1Kwn
• Name: potassium inwardly-rectifying channel, subfamily J, member 6; targeted mutation 1.1, Kevin D Wickman
• MGI ID: MGI:5752943
• Synonyms: Girk2^flox
• Gene: Kcnj6 Location: Chr16:94549495-94798560 bp, - strand Genetic Position: Chr16, 55.44 cM
• Alliance: Kcnj6^tm1.1Kwn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221645
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 4 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:221645)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnj6 Mutation: 29 strains or lines available

References

• Original: J:221645 Kotecki L, et al., GIRK Channels Modulate Opioid-Induced Motor Activity in a Cell Type- and Subunit-Dependent Manner. J Neurosci. 2015 May 6;35(18):7131-42
• All: 9 reference(s)