Cul3^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Cul3^tm1.1Arte
• Name: cullin 3; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:5752857
• Synonyms: CUL3^delta403-459
• Gene: Cul3 Location: Chr1:80242640-80318197 bp, - strand Genetic Position: Chr1, 41.24 cM, cytoband C4
• Alliance: Cul3^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229424
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: Flp-mediated recombination removed the FRT flanked PuroR cassette that was inserted into exon 9 at residues 403-459, resulting in an exon 9 deletion of these residues. Western blotting confirmed expression of the expected deleted form in kidney. (J:229424)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cul3 Mutation: 50 strains or lines available

References

• Original: J:229424 Schumacher FR, et al., Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia. EMBO Mol Med. 2015 Oct;7(10):1285-306
• All: 1 reference(s)