Phenotypes associated with this allele

• Allele Symbol: Cul3^tm1.1Arte
• Allele Name: targeted mutation 1.1, TaconicArtemis
• Allele ID: MGI:5752857
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cul3^tm1.1Arte/Cul3^tm1.1Arte	involves: C57BL/6J * C57BL/6N	MGI:5752859
ht2	Cul3^tm1.1Arte/Cul3^+	involves: C57BL/6J * C57BL/6N	MGI:5752860

Genotype
MGI:5752859

hm1

• Allelic Composition: Cul3^tm1.1Arte/Cul3^tm1.1Arte
• Genetic Background: involves: C57BL/6J * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:229424 )

• no homozygotes are born

Genotype
MGI:5752860

ht2

• Allelic Composition: Cul3^tm1.1Arte/Cul3⁺
• Genetic Background: involves: C57BL/6J * C57BL/6N

cardiovascular system

increased aorta wall thickness ( J:229424 )

hypertension ( J:229424 )

• mice under general anesthesia exhibit higher blood pressure

abnormal blood vessel physiology ( J:229424 )

• the systolic aortic pressure wave is augmented while the diastolic relaxation is slowed, suggesting early wave reflection of the pressure wave and compliance changes indicating vascular stiffness

increased vasoconstriction ( J:229424 )

• maximal constrictor response to intravenous administration of phenylephrine and angiotensin II are higher than in wild-type mice

growth/size/body

decreased body weight ( J:229424 )

decreased body length ( J:229424 )

homeostasis/metabolism

increased circulating aldosterone level ( J:229424 )

increased circulating magnesium level ( J:229424 )

increased circulating phosphate level ( J:229424 )

hyperkalemia ( J:229424 )

increased circulating chloride level ( J:229424 )

• mice exhibit hyperchloremia

abnormal pH regulation ( J:229424 )

• pH is maintained by an increased respiratory drive to increase CO2 removal and hence reduced total CO2 and pCO2 levels

metabolic acidosis ( J:229424 )

• compensated metabolic acidosis

muscle

increased vasoconstriction ( J:229424 )

• maximal constrictor response to intravenous administration of phenylephrine and angiotensin II are higher than in wild-type mice