Malt1^tm2.1Jrld
Targeted Allele Detail

Summary

• Symbol: Malt1^tm2.1Jrld
• Name: MALT1 paracaspase; targeted mutation 2.1, Jurgen Ruland
• MGI ID: MGI:5752611
• Synonyms: Malt1^PM
• Gene: Malt1 Location: Chr18:65564010-65612138 bp, + strand Genetic Position: Chr18, 38.56 cM
• Alliance: Malt1^tm2.1Jrld page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:225698
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 11 was replaced with a floxed neomycin resistance cassette and a modified exon 11 in which nucleotide substitution (TGT CGC to GCG CGC) results in the amino acid substitution of cysteine with alanine at position 472 (C472A) and a silent mutation at codon 473. Cre-mediated recombination removed the selection cassette. (J:225698)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Malt1 Mutation: 33 strains or lines available

References

• Original: J:225698 Gewies A, et al., Uncoupling Malt1 threshold function from paracaspase activity results in destructive autoimmune inflammation. Cell Rep. 2014 Nov 20;9(4):1292-305
• All: 5 reference(s)