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Targeted Allele Detail
Symbol: Scyl2tm1.1Spel
Name: SCY1-like 2 (S. cerevisiae); targeted mutation 1.1, Stephane Pelletier
MGI ID: MGI:5752500
Synonyms: Scyl2fl
Gene: Scyl2  Location: Chr10:89638721-89686285 bp, - strand  Genetic Position: Chr10, 45.05 cM
Germline Transmission:  Earliest citation of germline transmission: J:225808
Parent Cell Line:  CMTI-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 4. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 8. Flp-mediated recombination removed the selection cassette and left exons 4 through 8 floxed. (J:225808)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scyl2 Mutation:  3 strains or lines available
Original:  J:225808 Gingras S, et al., SCYL2 Protects CA3 Pyramidal Neurons from Excitotoxicity during Functional Maturation of the Mouse Hippocampus. J Neurosci. 2015 Jul 22;35(29):10510-22
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory