Itk^tm1.1Gsk
Targeted Allele Detail

Summary

• Symbol: Itk^tm1.1Gsk
• Name: IL2 inducible T cell kinase; targeted mutation 1.1, GlaxoSmithKline
• MGI ID: MGI:5750989
• Synonyms: Itk^K390R
• Gene: Itk Location: Chr11:46215977-46280342 bp, - strand Genetic Position: Chr11, 27.75 cM
• Alliance: Itk^tm1.1Gsk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222505
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 12 was replaced with a floxed, modified exon 12 in which nucleotide substitution results in the amino acid substitution of arginine for lysine at position 390 (K390R). Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted downstream of the modified exon 12. (J:222505)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itk Mutation: 51 strains or lines available

References

• Original: J:222505 Deakin A, et al., Characterisation of a K390R ITK kinase dead transgenic mouse--implications for ITK as a therapeutic target. PLoS One. 2014;9(9):e107490
• All: 1 reference(s)