Hmgb1^tm1.1Ebc
Targeted Allele Detail

Summary

• Symbol: Hmgb1^tm1.1Ebc
• Name: high mobility group box 1; targeted mutation 1.1, Eugene B Chang
• MGI ID: MGI:5749541
• Synonyms: Hmgb1^f
• Gene: Hmgb1 Location: Chr5:148983512-148989867 bp, - strand Genetic Position: Chr5, 89.18 cM
• Alliance: Hmgb1^tm1.1Ebc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220375
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Exons 2 and 3 were floxed via homologous recombination. (J:220375)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hmgb1 Mutation: 15 strains or lines available

References

• Original: J:220375 Zhu X, et al., Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation. J Clin Invest. 2015 Mar 2;125(3):1098-110
• All: 4 reference(s)