Wsb1^tm1Acb
Targeted Allele Detail

Summary

• Symbol: Wsb1^tm1Acb
• Name: WD repeat and SOCS box-containing 1; targeted mutation 1, Antonio C Bianco
• MGI ID: MGI:5749519
• Synonyms: Wsb1^fl
• Gene: Wsb1 Location: Chr11:79130198-79145497 bp, - strand Genetic Position: Chr11, 46.74 cM, cytoband B5
• Alliance: Wsb1^tm1Acb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220398
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 6 and a loxP site and FRT flanked neo cassette were inserted downstream of exon 7 via homologous recombination. (J:220398)

Generation of the Wsb1^tm1Acb allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wsb1 Mutation: 25 strains or lines available

References

• Original: J:220398 Werneck de Castro JP, et al., Differences in hypothalamic type 2 deiodinase ubiquitination explain localized sensitivity to thyroxine. J Clin Invest. 2015 Feb;125(2):769-81
• All: 1 reference(s)