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Tjp1tm1.1Whun
Targeted Allele Detail
Nomenclature
Symbol: Tjp1tm1.1Whun
Name: tight junction protein 1; targeted mutation 1.1, Walter Hunziker
MGI ID: MGI:5749399
Synonyms: Tjp1flox
Gene: Tjp1  Location: Chr7:64945913-65177529 bp, - strand  Genetic Position: Chr7, 35.02 cM
Growth retardation and severe glomerulosclerosis in Tjp1tm1.1Whun/Tjp1tm1.1WhunTg(Nphs1-cre)33Mska/0 mice

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:226210
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsAn FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 4. An F3 site flanked pyromycin resistance cassette with a 3' loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the selection markers and left exon 4 floxed. (J:226210)
Generation of the Tjp1tm1.1Whun allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tjp1 Mutation:  43 strains or lines available
References
Original:  J:226210 Itoh M, et al., The structural and functional organization of the podocyte filtration slits is regulated by Tjp1/ZO-1. PLoS One. 2014;9(9):e106621
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory