Map4k4^tm1.1Wye
Targeted Allele Detail

Summary

• Symbol: Map4k4^tm1.1Wye
• Name: mitogen-activated protein kinase kinase kinase kinase 4; targeted mutation 1.1, Weilan Ye
• MGI ID: MGI:5749394
• Synonyms: Map4k4^fl
• Gene: Map4k4 Location: Chr1:39940073-40065470 bp, + strand Genetic Position: Chr1, 18.53 cM, cytoband B
• Alliance: Map4k4^tm1.1Wye page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220464
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 6 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 6 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:220464)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map4k4 Mutation: 104 strains or lines available

References

• Original: J:220464 Vitorino P, et al., MAP4K4 regulates integrin-FERM binding to control endothelial cell motility. Nature. 2015 Mar 26;519(7544):425-30
• All: 3 reference(s)