Prmt5^tm1.2Masu
Targeted Allele Detail

Summary

• Symbol: Prmt5^tm1.2Masu
• Name: protein arginine N-methyltransferase 5; targeted mutation 1.2, M Azim Surani
• MGI ID: MGI:5708842
• Gene: Prmt5 Location: Chr14:54744639-54754927 bp, - strand Genetic Position: Chr14, 27.82 cM, cytoband C1
• Alliance: Prmt5^tm1.2Masu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:219506
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and an FRT flanked pgk-neo cassette in inverse orientation were inserted into intron 6 and a loxP site was inserted intron 7. Recombinase mediated recombination removed the neo cassette and exon 7. (J:219506)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prmt5 Mutation: 44 strains or lines available

References

• Original: J:219506 Kim S, et al., PRMT5 protects genomic integrity during global DNA demethylation in primordial germ cells and preimplantation embryos. Mol Cell. 2014 Nov 20;56(4):564-79
• All: 1 reference(s)