Krt6a^{tm1.1(HBEGF)Fmc}
Targeted Allele Detail

Summary

• Symbol: Krt6a^{tm1.1(HBEGF)Fmc}
• Name: keratin 6A; targeted mutation 1.1, Frank McKeon
• MGI ID: MGI:5707717
• Synonyms: Krt6-DTR
• Gene: Krt6a Location: Chr15:101598363-101602746 bp, - strand Genetic Position: Chr15, 56.97 cM
• Alliance: Krt6a^{tm1.1(HBEGF)Fmc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:218398
• Parent Cell Line: v6.4 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutation: Insertion
• Krt6a^{tm1.1(HBEGF)Fmc} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBEGF (1839)

  Hbegf

  (MGI:96070)

• Mutation details: Exons 1-4 were replaced with a human HBEGF cDNA and a floxed neo cassette via homologous recombination. Cre mediated recombination removed the neo cassette. (J:218398)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Krt6a Mutation: 25 strains or lines available

References

• Original: J:218398 Zuo W, et al., p63(+)Krt5(+) distal airway stem cells are essential for lung regeneration. Nature. 2015 Jan 29;517(7536):616-20
• All: 1 reference(s)