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Leptm1.1Gvcao
Targeted Allele Detail
Summary
Symbol: Leptm1.1Gvcao
Name: leptin; targeted mutation 1.1, Gwen Childs
MGI ID: MGI:5707692
Synonyms: Leptinfl
Gene: Lep  Location: Chr6:29060220-29073875 bp, + strand  Genetic Position: Chr6, 12.3 cM
Alliance: Leptm1.1Gvcao page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:218720
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 3. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette and left exon 3 floxed. (J:218720)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lep Mutation:  19 strains or lines available
References
Original:  J:218720 Odle AK, et al., Adipocyte versus pituitary leptin in the regulation of pituitary hormones: somatotropes develop normally in the absence of circulating leptin. Endocrinology. 2014 Nov;155(11):4316-28
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory