Analysis Tools
reproductive system
infertility
(
J:218720
)
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• both male and female mutant mice are infertile
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growth/size/body
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• male and female mutant mice weigh significantly more than controls by postnatal day 21 and continue to gain weight into adulthood
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homeostasis/metabolism
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• adult male, but not female, mutants exhibit significantly decreased circulating FSH levels relative to controls
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• adult female, but not male, mutants show significantly decreased circulating LH levels relative to controls
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• adult female, but not male, mutants show significantly decreased circulating prolactin levels relative to controls
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• male and female mutant mice lack adipose leptin protein and do not produce any detectable circulating serum leptin levels, indicating that circulating leptin is mainly or completely produced by adipocytes with no contribution from the pituitary
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• adult male, but not female, mutants show a trend toward a reduction in serum GH levels, although the result is not significant relative to controls
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• primary pituitary cells derived from adult male mutant mice show an increased % of cells immunolabeled for leptin relative to control pituitary cells
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endocrine/exocrine glands
| N |
• primary pituitary cells derived from adult male and female mutant mice show no significant difference in the % of cells immunolabeled for growth hormone (GH) relative to control pituitary cells
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