Dnajc11^spc
Chemically induced Allele Detail

Summary

• Symbol: Dnajc11^spc
• Name: DnaJ heat shock protein family (Hsp40) member C11; spastic
• MGI ID: MGI:5707591
• Synonyms: Dnajc11^m1Edou
• Gene: Dnajc11 Location: Chr4:152018177-152066416 bp, + strand Genetic Position: Chr4, 82.77 cM
• Alliance: Dnajc11^spc page

Mutation origin

• Strain of Origin: C57BL/6J x 129S6/SvEvTac

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to A point mutation in the splice acceptor site of intron 14 that results in the incorporation of 109 bp intronic sequence into the mature transcript and a premature termination codon. (J:221543)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dnajc11 Mutation: 57 strains or lines available

References

• Original: J:221543 Ioakeimidis F, et al., A splicing mutation in the novel mitochondrial protein DNAJC11 causes motor neuron pathology associated with cristae disorganization, and lymphoid abnormalities in mice. PLoS One. 2014;9(8):e104237
• All: 1 reference(s)