Ltf^tm1.2Smoc
Targeted Allele Detail

Summary

• Symbol: Ltf^tm1.2Smoc
• Name: lactotransferrin; targeted mutation 1.2, Shanghai Model Organisms Center
• MGI ID: MGI:5707374
• Synonyms: Lf^-, Ltf^tm1.2Srcmo
• Gene: Ltf Location: Chr9:110848360-110871834 bp, + strand Genetic Position: Chr9, 60.79 cM, cytoband F
• Alliance: Ltf^tm1.2Smoc page

Ltf^tm1.2Smoc/Ltf^tm1.2Smoc mice show greater susceptibility to AOM-DSS-induced colorectal dysplasia

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:219007
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette and left exon 3 floxed. Cre-mediated recombination removed exon 3. Western blot analysis confirmed the absence of protein expression in bone marrow. (J:219007)

Generation of the Ltf^tm1.1Smoc and Ltf^tm1.2Smoc alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ltf Mutation: 40 strains or lines available

References

• Original: J:219007 Ye Q, et al., Lactoferrin deficiency promotes colitis-associated colorectal dysplasia in mice. PLoS One. 2014;9(7):e103298
• All: 2 reference(s)