Phenotypes associated with this allele

• Allele Symbol: Ltf^tm1.2Smoc
• Allele Name: targeted mutation 1.2, Shanghai Model Organisms Center
• Allele ID: MGI:5707374
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ltf^tm1.2Smoc/Ltf^tm1.2Smoc	involves: 129 * C57BL/6J	MGI:5789942

Genotype
MGI:5789942

hm1

• Allelic Composition: Ltf^tm1.2Smoc/Ltf^tm1.2Smoc
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Ltf^tm1.2Smoc/Ltf^tm1.2Smoc mice show greater susceptibility to AOM-DSS-induced colorectal dysplasia

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:219007 )

♂ • following challenge with low-dose azoxymethane (AOM)-dextran sulfate sodium (DSS)-induced intestinal inflammation for 18 weeks, all mice develop colitis with macroscopic lesions in the middle to distal regions of the colon while 31% exhibit colorectal dysplasia characterized by loss of epithelial polarity, unlike wild-type controls which develop colitis, but not dysplasia or cancer

♂ • however, unchallenged mice develop normally and show no gross morphological abnormalities under normal physiological conditions

neoplasm

increased incidence of tumors by chemical induction ( J:219007 )

♂ • following challenge with low-dose azoxymethane (AOM)-dextran sulfate sodium (DSS)-induced intestinal inflammation for 18 weeks, all mice develop colitis with macroscopic lesions in the middle to distal regions of the colon while 31% exhibit colorectal dysplasia characterized by loss of epithelial polarity, unlike wild-type controls which develop colitis, but not dysplasia or cancer

♂ • however, unchallenged mice develop normally and show no gross morphological abnormalities under normal physiological conditions

cellular

decreased apoptosis ( J:219007 )

♂ • after 18 weeks on the AOM-DSS protocol, mice show a significantly lower level of the pro-apoptotic protein Bax in colonic tissues, and significantly decreased rates of apoptosis by TUNEL staining of Swiss roll colons, relative to wild-type controls

increased cell proliferation ( J:219007 )

♂ • after 18 weeks on the AOM-DSS protocol, mice show a significantly higher proliferation rate in colonic tissues than wild-type controls