Gucy2g^tm2.2Rbya
Targeted Allele Detail

Summary

• Symbol: Gucy2g^tm2.2Rbya
• Name: guanylate cyclase 2g; targeted mutation 2.2, Ruey-Bing Yang
• MGI ID: MGI:5707293
• Synonyms: Gucy2g^delta
• Gene: Gucy2g Location: Chr19:55186531-55229668 bp, - strand Genetic Position: Chr19, 51.18 cM, cytoband D2
• Alliance: Gucy2g^tm2.2Rbya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:218251
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 16 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 18 via homologous recombination. Flp and cre mediated recombination removed the neo cassette and exons 16-18. (J:218251)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gucy2g Mutation: 60 strains or lines available

References

• Original: J:218251 Chao YC, et al., Receptor guanylyl cyclase-G is a novel thermosensory protein activated by cool temperatures. EMBO J. 2015 Feb 3;34(3):294-306
• All: 1 reference(s)