Tg(OPTN*E50K,-EGFP)1Mde
Transgene Detail
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Symbol: |
Tg(OPTN*E50K,-EGFP)1Mde |
Name: |
transgene insertion 1, Michael D Ehlers |
MGI ID: |
MGI:5705748 |
Synonyms: |
BAC-hOPTNE50K |
Transgene: |
Tg(OPTN*E50K,-EGFP)1Mde Location: unknown
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Alliance: |
Tg(OPTN*E50K,-EGFP)1Mde page
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence, Reporter) |
Mutation: |
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Insertion
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Tg(OPTN*E50K,-EGFP)1Mde expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
OPTN (10133) |
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Mutation details: The transgene is composed of BAC clone RP11-1107F3 containing the 38 kb-human OPTN locus with about 160 kb of 5 sequence containing the E50K mutation in the middle (GAG to AAG) and a fragment containing the internal ribosome entry site-enhanced green fluorescent protein. Two lines were established, 1 and 2. Line 1 shows overexpression of the gene but line 2 does not. Quantitative rtPCR and immunoblot analysis confirmed mRNA expression and protein expression in the retina.
(J:222642)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:222642 Tseng HC, et al., Visual impairment in an optineurin mouse model of primary open-angle glaucoma. Neurobiol Aging. 2015 Jun;36(6):2201-12 |
All: |
1 reference(s) |
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