Hmgb1^tm1.1Dltg
Targeted Allele Detail

Summary

• Symbol: Hmgb1^tm1.1Dltg
• Name: high mobility group box 1; targeted mutation 1.1, Daolin Tang
• MGI ID: MGI:5704391
• Synonyms: HMGB1^flox
• Gene: Hmgb1 Location: Chr5:148983512-148989867 bp, - strand Genetic Position: Chr5, 89.18 cM
• Alliance: Hmgb1^tm1.1Dltg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:225260
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 were floxed. Flp-mediated recombination removed the neomycin resistance cassette inserted downstream of exon 3. (J:225257, J:225260)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Hmgb1^tm1.1Dltg

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hmgb1 Mutation: 15 strains or lines available

References

• Original: J:225260 Kang R, et al., Intracellular Hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice. Gastroenterology. 2014 Apr;146(4):1097-107
• All: 11 reference(s)