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Targeted Allele Detail
Symbol: Ireb2tm1.1Eal
Name: iron responsive element binding protein 2; targeted mutation 1.1, Elizabeth A Leibold
MGI ID: MGI:5702744
Synonyms: Irp2-
Gene: Ireb2  Location: Chr9:54863789-54912530 bp, + strand  Genetic Position: Chr9, 29.81 cM
Iron accumulates in specific brain regions of Ireb2tm1.1Eal/Ireb2tm1.1Eal mice

Show the 6 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:217335
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA construct containing a FLAG-tagged human ACO1 cDNA and a self-excising neo cassette was inserted into exon 3. mRNA expression of the FLAG-tagged human cDNA is detected but no protein expression is detected. (J:217335)
Generation of the Ireb2tm1.1Eal allele
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 14 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ireb2 Mutation:  41 strains or lines available
Original:  J:217335 Zumbrennen-Bullough KB, et al., Abnormal brain iron metabolism in Irp2 deficient mice is associated with mild neurological and behavioral impairments. PLoS One. 2014;9(6):e98072
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory