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Targeted Allele Detail
Symbol: Gata6tm1Hadj
Name: GATA binding protein 6; targeted mutation 1, Anna-Katerina Hadjantonakis
MGI ID: MGI:5700508
Synonyms: Gata6H2B-Venus, Gata6tm1(HIST1H2BB/Venus)Hadj
Gene: Gata6  Location: Chr18:11052510-11085636 bp, + strand  Genetic Position: Chr18, 5.63 cM
Germline Transmission:  Earliest citation of germline transmission: J:226600
Parent Cell Line:  KH2 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsThe targeting vector is designed to insert downstream of the first non-coding intron with (from 3' to 5') an FRT site, engrailed 2 intron and exon with splice acceptor site, H2B-Venus-polyadenylation sequence, rox-flanked beta actin promoter driven NEO cassette, and a loxP site, followed by exon 2 and a second loxP site. Two alternative translation initiation codons are present in exon 2. (J:226600, J:227467)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gata6 Mutation:  19 strains or lines available
The allele was made in KH2 cells that carry Gt(ROSA)26Sortm1(rtTA*M2)Jae and Col1a1tm2(tetO-Pou5f1)Jae (J:159351).
Original:  J:226600 Freyer L, et al., A loss-of-function and H2B-Venus transcriptional reporter allele for Gata6 in mice. BMC Dev Biol. 2015;15:38
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory