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QTL Variant Detail
QTL variant: Pas18C3H/HeJ
Name: pulmonary adenoma susceptibility 18; C3H/HeJ
MGI ID: MGI:5699165
QTL: Pas18  Location: Chr6:145216699-145250239 bp  Genetic Position: Chr6, Syntenic
Strain of Specimen:  C3H/HeJ
Allele Type:    QTL

Mapping and Phenotype information for this QTL, its variants and associated markers


The authors mapped the Pas1 lung cancer susceptibility locus using 193 female (BALB/cJ x C3H/HeJ)F2 mice induced with i.p. injections of urethane. SWR/J, BALB/cJ and C3H/HeJ strains are susceptible, intermediately susceptible and resistant to lung tumorigenesis, respectively. F2 mice were analyzed with following loci: D6Mit8, D6Mit32, D6Mit291, D6Mit198, D6Mit157, Kras, D6Mit201, and D6Int1. A peak LOD score of 28.4 was associated with Kras.

12.16.2015 Curator Note: Because Pas1 was orginally mapped in J:17778, in 1997 using an (C57BL/6J x A/J)F2 intercross, which differs from the cross used here, which differs from the cross used here, we consider the current study a separate mapping experiment and have named this QTL Pas18 .

Researchers attempted to confirm the mapping in (BALB/cJ x SWR/J)F2 animals, but no polymorphism could be found at the Kras2 locus, suggesting these strains may share the same Pas1 allele (additionally, no association between Pas1 and D6Mit114, D6Mit294 or D6Mit115 was found).

Original:  J:44025 Manenti G, et al., Pas1 is a common lung cancer susceptibility locus in three mouse strains. Mamm Genome. 1997;8(11):801-4
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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