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Targeted Allele Detail
Symbol: Cd160tm1Yxf
Name: CD160 antigen; targeted mutation 1, Yang-Xin Fu
MGI ID: MGI:5698520
Gene: Cd160  Location: Chr3:96798763-96829351 bp, - strand  Genetic Position: Chr3, 41.99 cM
Germline Transmission:  Earliest citation of germline transmission: J:222131
Parent Cell Line:  PRX-B6N (ES Cell)
Strain of Origin:  C57BL/6NTac
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThe targeting vector was designed to replace exon 2 with a PGK-neo cassette. Exon 2 contains the initiation codon and is required for all splice variants. Removal of exon 2 forces downstream exons out of frame. Testing by immunohistochemistry confirms the absence of protein. (J:222131)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cd160 Mutation:  6 strains or lines available
Original:  J:222131 Tu TC, et al., CD160 is essential for NK-mediated IFN-gamma production. J Exp Med. 2015 Mar 9;212(3):415-29
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
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