About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd160tm1Yxf
targeted mutation 1, Yang-Xin Fu
MGI:5698520
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cd160tm1Yxf/Cd160tm1Yxf C57BL/6-Cd160tm1Yxf MGI:5702313
cx2
 		Cd160tm1Yxf/Cd160tm1Yxf
Rag1tm1Mom/Rag1tm1Mom 		B6.Cg-Rag1tm1Mom Cd160tm1Yxf MGI:5702315


Genotype
MGI:5702313
hm1
Allelic
Composition		 Cd160tm1Yxf/Cd160tm1Yxf
Genetic
Background		 C57BL/6-Cd160tm1Yxf
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd160tm1Yxf mutation (1 available); any Cd160 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interferon-gamma secretion ( J:222131 )
• reduced interferon gamma production from splenocytes stimulated by Nk1.1 cross-linking

neoplasm
increased tumor growth/size ( J:222131 )
• increased tumor volume following inoculation with NK-dependent B16 tumor cells as compared to inoculated wild-type mice




Genotype
MGI:5702315
cx2
Allelic
Composition		 Cd160tm1Yxf/Cd160tm1Yxf
Rag1tm1Mom/Rag1tm1Mom
Genetic
Background		 B6.Cg-Rag1tm1Mom Cd160tm1Yxf
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd160tm1Yxf mutation (1 available); any Cd160 mutation (17 available)
Rag1tm1Mom mutation (49 available); any Rag1 mutation (120 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interferon-gamma secretion ( J:222131 )
• reduced interferon gamma production from splenocytes stimulated by Nk1.1 cross-linking

neoplasm
increased tumor growth/size ( J:222131 )
• increased tumor volume/weight following inoculation with NK-dependent B16 or RMA-S (no MHC class I surface expression) tumor cells as compared to homozygous Ragtm1Mom control
• tumors generated by inoculation with RMA (normal MHC class I) cells have weights similar to Ragtm1Mom controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory