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Pde9atm1Pfi
Targeted Allele Detail
Nomenclature
Symbol: Pde9atm1Pfi
Name: phosphodiesterase 9A; targeted mutation 1, Pfizer, Ltd
MGI ID: MGI:5697082
Gene: Pde9a  Location: Chr17:31386212-31476310 bp, + strand  Genetic Position: Chr17, 16.23 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:220465
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 12 was replaced with a lacZ-neomycin cassette in the catalytic domain of the carboxy terminal of the gene via homologous recombination. (J:220465)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pde9a Mutation:  31 strains or lines available
References
Original:  J:220465 Lee DI, et al., Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease. Nature. 2015 Mar 26;519(7544):472-6
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory