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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pde9atm1Pfi
targeted mutation 1, Pfizer, Ltd
MGI:5697082
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pde9atm1Pfi/Pde9atm1Pfi Not Specified MGI:5697084


Genotype
MGI:5697084
hm1
Allelic
Composition		 Pde9atm1Pfi/Pde9atm1Pfi
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pde9atm1Pfi mutation (0 available); any Pde9a mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased response of heart to induced stress ( J:220465 )
• mice exposed to sustained pressure overload develop less dilation and dysfunction, and exhibit reduced heart and lung weights, interstitial fibrosis, and myocyte hypertrophy compared to transverse aortic constricted controls

homeostasis/metabolism
decreased response of heart to induced stress ( J:220465 )
• mice exposed to sustained pressure overload develop less dilation and dysfunction, and exhibit reduced heart and lung weights, interstitial fibrosis, and myocyte hypertrophy compared to transverse aortic constricted controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory