Dlg5^m1Alk
Chemically induced Allele Detail

Summary

• Symbol: Dlg5^m1Alk
• Name: discs large MAGUK scaffold protein 5; mutation 1, Alex L Kolodkin
• MGI ID: MGI:5695070
• Synonyms: Dlg5^LP
• Gene: Dlg5 Location: Chr14:24184021-24295988 bp, - strand Genetic Position: Chr14, 14.26 cM
• Alliance: Dlg5^m1Alk page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU) (Null/knockout)
• Mutation: Single point mutation
• Mutation details: A T-to-C transition was identified in exon 26 as the genetic mutation responsible for the phenotype. This is predicted to result in a L1642P amino acid substitution in the encoded protein. (J:216499)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dlg5 Mutation: 126 strains or lines available

References

• Original: J:216499 Wang SH, et al., Dlg5 regulates dendritic spine formation and synaptogenesis by controlling subcellular N-cadherin localization. J Neurosci. 2014 Sep 17;34(38):12745-61
• All: 1 reference(s)