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QTL Variant Detail
QTL variant: Bbaa25C3H/HeJ
Name: B.burgdorferi-associated arthritis 25; C3H/HeJ
MGI ID: MGI:5693831
QTL: Bbaa25  Location: Chr5:126090176-126090317 bp  Genetic Position: Chr5, Syntenic
Strain of Specimen:  C3H/HeJ
Allele Type:    QTL

Mapping and Phenotype information for this QTL, its variants and associated markers


Composite interval mapping (CIM) was used for localization of QTL involved in modulating response to infection with Borrelia burgdorferi. Parental strains C3H/HeN and C3H/HeJ are susceptible to B.burgdorferi-induced arthritis whereas parental strains C57BL/6N and BALB/cAnN are resistant. Four different backcrosses and the reanalysis of a previous intercross were performed.

In the (C57BL/6N x C3H/HeN) x C57BL/6N backcross authors state that previoulsy identified QTL Bbaa2 and Bbaa6, on Chrs 5 and 12 respectively, were reproduced.

[10.28.2015 Curator Note: Because Bbaa2 and Bbaa6 were originally mapped in J:52017 in 1999 using an (C3H/HeNCr x C57BL/6NCr)F2 intercross which differs from the backcross used here, we consider the current study a separate mapping experiment and have named the Chr 5 QTL Bbaa24 and the Chr 12 QTL Bbaa27.]

On Chr 5 Bbaa24 is linked to ankle swelling, mapping from 66-81 cM between markers D5Mit431 and D5Mit101 with an LRT of 31.7 accounting for 12.0% of trait variance. The QTLis also linked to histopathology, mapping from 66-78 cM between markers D5Mit431 and D5Mit98 with an LRT of 20.8 accounting for 8.8% of the trait variance. [Table 2.]

In the (C57BL/6N x C3H/HeN) x C57BL/6N backcross another Chr 5 QTL linked to tendon sheath mapped to 70 cM with marker D5Mit214, LRT=16.1 accounting for 12.9% of the variance. Authors also equate this QTL with the previoulsy identified Bbaa2. [Curator Note: Since the cross used here also differs from the orginal mapping population for Bbaa2 we have named this QTL, Bbaa25.] [Table 2.]

In the (C3H/HeJ x BALB/cAnN) x C3H/HeJ backcross another QTL that was also equated with Bbaa2 was mapped. [Curator Note: Since the cross used here also differs from the orginal mapping population for Bbaa2 we have named this QTL, Bbaa26.] [Table 2.]

Bbaa26 maps to Chr 5 linked to ankle swelling at 72 cM with marker D5Mit30, LRT=47.1 accounting for 29% variance. It also linked to histopathology from 56-78 cM between markers D5Mit115 and D5Mit31, LRT=33.4 accounting for 20.6% of variance and to tendon histology from 58-72 cM between markers D5Mit239 and D5Mit30, LRT=24.7 accounting for 16.0% variance. [Table 2.]

The reanalysis of the (C57BL/6N X C3H/HeN)F2 intercross also confirmed the previoulsy identified QTL Bbaa2 and Bbaa3 on Chr 5. Using CIM Bbaa2, linked to ankle swelling, mapped to 73.0 cM with marker D5Mit63, LRT=18.7. Bbaa3, linked to histopathology, mapped from 53.0 - 60.0 cM between markers D5Mit91 and D5Mit24, LRT=25.1 [Table 3.]

C3H/HeN-derived alleles are associated with increased arthritis susceptibility and severity at all QTL mapped in this experiment.

Original:  J:73060 Roper RJ, et al., Genetic control of susceptibility to experimental Lyme arthritis is polygenic and exhibits consistent linkage to multiple loci on chromosome 5 in four independent mouse crosses. Genes Immun. 2001 Nov;2(7):388-97
All:  1 reference(s)

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